Chain'd Out from ALR
Industries sets a standard for optimal performance supplementation.
Chain'd Out.. allows everyone to enjoy supraphysiological and aesthetic
results with Non-Hormonal Branch Chain Amino Acids (BCAA's)!
Did You Know That BCAA's Can Be Anabolic?
(If they are correctly structured, protected and delivered right)
The true value of BCAAs supplementation is finally well
established both in literature and in real world application: Anabolic
(muscle building) stimuli is their true value rather than wasting good
proteins to catabolism (muscle wasting) and more money landing in your
toilet.
What Are BCAA's?
BCAA's are the branch chain amino acids leucine, valine and
isoleucine. Also note that all amino acids are derived from the
assimilation of proteins. BCAA's are not only 3 of the paramount 18-22
amino acids (as in your body cannot make them and needs them to live),
they alone also make up about 70% of your muscle cellular pool and
cellular structure. Unfortunately, BCAAs are lost (...muscle loss) at a
rapid rate during training and during calorie deficient diets. The
result is less muscle and the need to replenish these muscle
mainstays...or better yet, trigger an anabolic environment that fosters
nutrient super-over-compensation where we need it- for accelerated
muscular growth. Why else do we train?
What Does The Research Say?
In one excellent study it was suggested that, "Branched-chain
amino acids activate key enzymes in protein synthesis after physical
exercise". J Nutr. 2006 Jan;136(1 Suppl):269S-73S researchers again
validated, "BCAA's (leucine, isoleucine, and valine), particularly
leucine, have anabolic effects on protein metabolism by increasing the
rate of protein synthesis and decreasing the rate of protein degradation
in resting human muscle."
In another study, we find validation that "Leucine regulates
translation initiation of protein synthesis in skeletal muscle after
exercise". J Nutr. 2006 Feb;136(2):533S-537S. Norton LE, Layman DK.
Researchers validate the mechanism by which the anabolic signal is
initiated: "High-performance physical activity and post-exercise
recovery lead to significant changes in amino acid and protein
metabolism in skeletal muscle. Central to these changes is an increase
in the metabolism of the BCAA leucine. During exercise, muscle protein
synthesis decreases together with a net increase in protein degradation
and stimulation of BCAA oxidation. BCAA oxidation increases through
activation of the branched-chain alpha-keto acid dehydrogenase (BCKDH).
BCKDH activity increases with exercise, reducing plasma and
intracellular leucine concentrations. After exercise, recovery of muscle
protein synthesis requires dietary protein or BCAA to increase tissue
levels of leucine in order to release the inhibition of the initiation
factor 4 complex through activation of the protein kinase mammalian
target of rapamycin (mTOR). Leucine's effect on mTOR is synergistic with
insulin via the phosphoinositol 3-kinase signaling pathway. Together,
insulin and leucine allow skeletal muscle to coordinate protein
synthesis with physiological state and dietary intake."
*A note from Author: One of the two highly respected researchers
who penned the peer-reviewed article above is named Layne Norton. To say
Layne is brilliant is an understatement. Please take some time to read
the complete study if you get a few minutes. It's worth your time!
And More....Of Course
Never being satisfied with simply good or even just excellent, ALR
Industries has taken BCAAs to the ultimate level for mind-blowing
effects. Author L. Rea decided to turn the power way up on "anabolic
drive" with Chain'd Out®. First, we utilized ester technology to
increase oral bio availability 200-300%. Yes, this means way more bang
for your buck. More importantly is that our ester-protected BCAA's
greatly avoid gluconeogenesis (break-down and conversion to glucose for
regular caloric utilization) very well. I mean why would you pay for a
BCAA with half to one third the oral bioavailability and risk the
majority of your muscle gains? Why not simply protect yourself from
catabolic muscle loss while adding more muscle instead?
ALR Industries has taken the science of adaptogens well beyond
anything seen before. Chain'd Out has a rock solid foundation, which is
further reinforced by boosting its overall synergy through the addition
of potent anti-catabolic agents, anabolic co-factors and last but
certainly not least it promotes increased mood boosting and energizing
effects. Author left no stone unturned in his passion to create the most
complete and highest orally bioavailable BCAA formula on the market.
Chain'd Out® is
scientifically engineered to potently thwart muscle breakdown and
catabolism. We made it to provide an incredible synergistic boost to the
pro-anabolic drive, produce focused energy and mood elevation (without
any jitters or negative stimulant qualities), improved strength,
endurance, stamina and recovery, create optimized vasodilation and
nutrient utilization, enhances oxygenation and fight stress, fatigue as
well as other counterproductive body processes.
Chain'd Out® Provides the Following Benefits:
Provides positive modulation of almost all neurotransmitters (DA, NE, SE, MAOB, Ach, GABA)
Enhances energy, focus, mood and stamina
Has potent anti-catabolic effects
Enhances oxygenation and nutrient utilization
Provides positive endogenous hormone modulation, including testosterone
Has anti-fatigue, anti-stress and anti-oxidant effects
Enhances immunity and recovery
Supports supraphysiological protein synthesis in muscle tissue
*Note you will feel the power of this matrix as it is noticeably effective within minutes.
Once again ALR Industries has raised the bar in sports
supplementation with its formula for Chain'd Out®. Chain'd Out® sets the
standard for non-hormonal performance by creating an
anabolic/anti-catabolic environment beyond your wildest expectations!
Chain'd Out® Q&A's
Q: I use another brand of BCAA's, what makes Chain'd Out® so special?
A: Other than ALR Industries winning best tasting formula and #1
BCAA matrix in both Australia and New Zealand? Well, all BCAA products
have value. Most are simply energy substrates during catabolic or
caloric restricted periods. If you are losing 50-66% of your BCAA
supplementation, it is not only non-cost effective and weak in
anti-catabolic support but it is also not anabolic. Chain'd Out® is
without a doubt, one of the only time release anabolic and
anti-catabolic formulas available. Gain lean mass now!
Q: Don't I Get Enough BCAA'S In My Protein Shake? I Though My Protein gave me all the Amino Acids I needed.
A: That depends upon how hard you train and how much lean mass you
want. BCAAs are about 70% of total muscle protein cell weight. When you
train, your body often dips into these muscle cells to steal BCAAs as a
source of energy to keep the muscles working. When this happens you
lose lean mass and much of your hard work is lost. Any BCAA product will
help, but the goal is not just to decrease the amount of lean
mass/BCAAs lost from training and stress. The goal is to get the
anabolic (growth) pay off you're working for. This requires properly
protected BCAAs and a time-release delivery such as we have created with
our unique alpha-hydroxy-ester technology. Get all you pay for, not
just a few % and start seeing and feeling the difference today.
Q: Do I use Chain'd Out® Before I Train or After?
A: In all honesty all three: Before, during and after training.
Not only does Chain'd Out taste amazing and have a refreshing
pro-recover affect you feel, it assures proper hydration and the
strongest anabolic and anti-catabolic environment. We have had amazing
positive mental and physiological results reported from mixing 1-3
servings of Chain'd Out® to the appropriate amount of cold water and
drinking between meals. This of course includes while training or in the
middle of the night. However, if you only have one chance to enjoy a
serving of your favorite flavor of Chain'd Out®, then drink it 15 minute
prior to training.
Q: Do I Take it with My Protein Shake or Meal?
A: All proteins break down into amino acids and some compete for
muscle receptor sites and/or enzymes. The result is something good may
get kicked out, like BCAAs. Since Chain'd Out® passes through the GI
rather quickly, you simply need to be sure you have not consumed
proteins for 2 hours prior or 20-30 minutes after ingestion. Pretty
simple, huh?
Q: I Noticed you didn't add any form of Glutamine to Chain'd Out®. Why?
A: As mentioned prior, amino acids can compete for muscle cell
receptors. They can also compete for GI up-take and digestion. Some
studies support glutamine and BCAAs are examples but there is far more
to the issue.
Metabolism of oral/dietary amino acids by the gut and liver has a
major impact on the amino acid profile reaching systemic (whole body)
circulation. Specific examples include removal of nearly 100% of dietary
glutamine and glutamate, 60% of threonine, and 40% of phenylalanine
during the absorption process largely by oxidative degradation
(degradation to carbon/glucose, ammonia and uric acid). The top
exceptions to this pattern of modifications are the BCAAs. Over 80% of
dietary content of leucine, valine, and isoleucine directly makes their
way to blood circulation. Unfortunately, once they make it to muscle
cells and the brain (other organs as well) they are easily converted
into glucose and glycogen (sugar) due to several physiological
action/reaction factors. Unless, of course, they are in a protected
time-release anti-catabolic/anabolic matrix.
1) Hyperammonemia is an over-abundance of ammonia in the body
resulting from the break-down of amino acids to ammonia and glucose
(gluconeogenesis for energy) which in turn increases the utilization of
branched-chain amino acids in muscle. This is especially prominant when
ketoglutarate is low, and is further enhanced by glutamine depletion.
Sounds like more glutamine would be cool then, huh? (At the right
time...it is)
Unfortunately not only is glutamine the most abundant amino acid,
it's also the most abundant gluconeogenic amino acid in the human body.
In fact its conversion to glucose is about equal to that of alanine. The
kidneys alone produce about 25% of whole body glucose production...from
glutamine. Now ponder the additional amount converted to glucose in
muscles and other organs then consider just how much circulatory and
muscle bound ammonia waste results. Now think about reconsidering the
first paragraph again: More ammonia (hyperammonemia) means more BCAAs
utilized for energy in/by muscle resulting in lean mass loss. Therefore,
a significant increase in blood glutamine concentration can signal
hyperammonemia and thus increased BCAA/lean muscle loss.
You know that ammonia smell you run into all over the gym? Yup, that is the smell of muscle loss. Is it you?
2) Tyrosine, which increases levels of dopamine and
nor-epinephrine, is also one of our substrates for glutamine. Tyrosine
competes with BCAAs absorption into the brain and low tyrosine can cause
loss of energy and fatigue. Since glutamine is a substrate of tyrosine,
ingesting BCAAs and glutamine together potentially hinders performance
as well resulting in lower intensity and less productive training or
performances.
3) An interesting study on BCAAs affects upon fatigue was
conducted in Japan: First Department of Internal Medicine, Okayama
University Medical School, 5-1, 2-chome, Shikata-cho, 700 Okayama, Japan
The molar ratio of excitatory amino acid neurotransmitters
(glutamate and aspartate) to inhibitory amino acid neurotransmitters
(raminobutyric acid, GABA, and glycine) in the brain was diminished in
acute hepatic failure rats with hyperammonemia, brain edema, and
abnormal electroencephalograms. The ratio was further decreased with a
marked elevation of arterial and brain ammonia levels 30 min after
ammonium acetate was administered i.p. to hepatic failure rats. A
continuous infusion of a branched chain amino acid (BCAA) solution
before and after the ammonia loading effectively reversed the
ammonia-induced lowering of this ratio; high ammonia contents in the
brain were concomitantly decreased. Infusing glutamate instead of the
BCAA solution failed to produce similar effects probably because of
limited entry of glutamate into the brain. The above results suggest
that excitatory and inhibitory amino acid neurotransmitter ratios
(glutamate, aspartate, and GABA) are positively affected by BCAAs. In
short, BCAA supplementation reduced brain/physical fatigue.
So more muscle and better
performance if we simply don't mix glutamine with BCAAs.Glutamine is
paramount to health and recovery, but timing is everything.
Q: Does Chain'd Out® Contain Any Sugars? I'm on a Keto Diet.
A: No, and more importantly it's far more difficult for
alpha-hydroxy-ester protected BCAAs to convert by way of gluconeogenesis
to glucose resulting in greater fat stores being used as energy
substrates. By adding anti-stress compounds to the Chain'd Out® matrix
the normal triggers of gluconeogenesis are reduced thus allowing for
increased true anabolism. Kind of cool, huh? Many who have added a
serving of Chain'd Out® to their morning cardio have noted the obvious
increase in fat loss yet commented on increased lean mass.
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